Cs cz became too big resolution fix9/10/2023 ![]() ![]() Here, we show that, rather than being an LDT, ElsL is actually a new class of cytoplasmic l, d-carboxypeptidase (LDC) that provides a critical step in cell wall recycling previously thought to be missing from A. ![]() ![]() Curiously, ElsL is composed of a leaderless YkuD-family domain usually found in secreted, cell wall-modifying l, d-transpeptidases (LDTs). We demonstrated previously that one of these unusual proteins, ElsL, is required for maintaining a characteristic short rod shape and for withstanding antibiotics that attack the septal cell wall. baumannii contains a number of poorly annotated proteins that may allow alternative mechanisms of envelope biogenesis. The bacterium, however, lacks many canonical enzymes that build the envelope in model organisms. The hospital-acquired pathogen Acinetobacter baumannii possesses a complex cell envelope that is key to its multidrug resistance and virulence.
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